New Insights from the Structure Function Analysis of the Catalytic Region of Human Platelet Pde3a: a Role for the Unique 44 Amino Acid Insert

NEW INSIGHTS FROM THE STRUCTURE FUNCTION ANALYSIS OF THE CATALYTIC REGION OF HUMAN PLATELET PDE3A: A ROLE FOR THE UNIQUE 44 AMINO ACID INSERT Su-Hwi Hung*, Wei Zhang*, Robin A. Pixley, Bradford A. Jameson, Yu Chu Huang, Roberta F. Colman and Robert W. Colman From the Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia PA, Department of Biochemistry, Drexel University College of Medicine, and Department of Chemistry and Biochemistry, University of Delaware, Newark DE Running title: Functional Role of the Unique Insert of PDE3A *S.H.H. and W.Z. made equal contributions to the paper. ‡ RFC and RWC were equal senior authors Address correspondence to: Robert W. Colman, the Sol Sherry Thrombosis Research Center, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140; Tel: 215-707-4665, Fax: 215-707-4855, E-mail: [email protected].